Some alkylphenols exhibit weak estrogenic effects in laboratory experiments. Based on the test system used and the specific isomer evaluated, the estrogenic potency of alkylphenol ranges from 1,000 to 1,000,000-fold less potent than that of oestradiol [the human female hormone]. Various gold-standard, high quality multigeneration studies have demonstrated that alkylphenols do not cause adverse effects on reproduction in mammals at doses that are not also systemically toxic. Likewise, in chronic fish toxicity studies, the effects of alkylphenols on population-health endpoints such as reproduction, development, growth and survival occur at very similar levels, indicating that ecotoxicity is not driven by specific estrogenic effects.

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